University Center for Physiology, Pathophysiology and Biophysics
Publications

Biophysical Properties of Somatic Cancer Mutations in the S4 Transmembrane Segment of the Human Voltage-Gated Proton Channel hHV1

Dr.rer. nat. Gustavo Chaves Barboza, Christophe Jardin, Christian Derst, Arne Franzen, Iryna Mahorivska, Thomas E DeCoursey, Boris Musset

Somatic HVCN1 mutations in cancer: Potential deleterious passenger mutations in the S4

Boris Musset , Biophysik;

Polyamines (PAs) but not small peptides with closely spaced positively charged groups interact with DNA and RNA, but they do not represent a relevant buffer system at physiological pH values

Julian Rieck, Christian Derst, Ruediger W. Veh , MODULATION; CYTOSOLIC PH; Spermine;

Interaction with stomatin directs human proton channels into cholesterol-dependent membrane domains

Artem G Ayuyan, Vladimir V Cherny, Gustavo Chaves, Boris Musset, Fredric S Cohen, Thomas E DeCoursey

Proton channels in molluscs: A new bivalvian‐specific minimal HV4 channel

Gustavo Chaves, Christophe Jardin, Arne Franzen, Iryna Mahorivska, Boris Musset, Christian Derst , PROTEIN; INHIBITION; Animals; Protons; PH; ALVEOLAR EPITHELIAL-CELLS; MOLECULAR-MECHANISM; SELECTIVITY FILTER; VOLTAGE; HYDROGEN-ION CURRENTS; GATING PORE; ZN2+; Mollusca/genetics; Amino Acids; Ion Channel Gating/physiology; Arginine; Ion Channels/metabolism;

Voltage-Gated Proton Channels in the Tree of Life

Gustavo Chaves, Christophe Jardin, Christian Derst, Boris Musset , Animals; HUMAN-NEUTROPHILS; Cell Membrane/metabolism; Protons; SUPEROXIDE-PRODUCTION; NADPH OXIDASE; ALVEOLAR EPITHELIAL-CELLS; MOLECULAR-MECHANISM; H+ CURRENTS; HYDROGEN-ION CURRENTS; OXIDASE-RELATED PROTON; ELECTRON CURRENTS; TEMPERATURE-DEPENDENCE; Respiratory Burst; Eukaryota/metabolism; Mammals/metabolism; Ion Channels/genetics;

Trapped Pore Waters in the Open Proton Channel Hv1

Danila Boytsov, Stefania Brescia, Gustavo Chaves, Sabina Koefler, Christof Hannesschlaeger, Christine Siligan, Nikolaus Goessweiner‐Mohr, Boris Musset, Peter Pohl , MODELS; DYNAMICS; CRYSTAL-STRUCTURE; MECHANISM; TRANSIENT PROTONATION; CONSERVED ASPARTATE; SELECTIVITY FILTER; PERMEATION; MEMBRANES;

Unexpected expansion of the voltage‐gated proton channel family

Gustavo Chaves, Artem G. Ayuyan, Vladimir V. Cherny, Deri Morgan, Arne Franzen, Lynne Fieber, Lydia Nausch, Christian Derst, Iryna Mahorivska, Christophe Jardin, Thomas E. DeCoursey, Boris Musset , INHIBITION; HUMAN-NEUTROPHILS; NADPH OXIDASE; PH; ALVEOLAR EPITHELIAL-CELLS; MOLECULAR-MECHANISM; WEB SERVER; HYDROGEN-ION CURRENTS; PERFUSED NEURONS; SNAIL;

Editorial for ‘Issue focus on 2nd Costa Rica biophysics symposium — March 11th–12th, 2021’

Gustavo Chaves, José Ángel Rodríguez-Corrales, Christopher Solís

Voltage‐gated proton channels in polyneopteran insects

Gustavo Chaves, Christian Derst, Christophe Jardin, Arne Franzen, Boris Musset , PROTEIN; HUMAN-NEUTROPHILS; NADPH OXIDASE; ALVEOLAR EPITHELIAL-CELLS; H+ CURRENTS; HYDROGEN-ION CURRENTS; ACID-BASE STATUS; PERFUSED NEURONS; VENTILATION RATE; TEMPERATURE;

Unexpected expansion of the voltage-gated proton channel family

G. Chaves, A. Ayuyan, VV Cherny, D. Morgan, A. Franzen, LA Fieber, L. Nausch, C. Derst, I. Mahorivska, C. Jardin, TE DeCoursey, B. Musset

Unexpected expansion of the voltage-gated proton channel family

G. Chaves, A. Ayuyan, VV Cherny, D. Morgan, A. Franzen, LA Fieber, L. Nausch, C. Derst, I. Mahorivska, C. Jardin, TE DeCoursey, B. Musset

The pH-dependent gating of the human voltage-gated proton channel from computational simulations

Christophe Jardin, Niklas Ohlwein, Arne Franzen, Gustavo Chaves, Boris Musset , INHIBITION; CRYSTAL-STRUCTURE; HUMAN-NEUTROPHILS; NADPH OXIDASE; ALVEOLAR EPITHELIAL-CELLS; SELECTIVITY FILTER; HV1; MOLECULAR-DYNAMICS; PERMEATION PATHWAY; H+ CURRENTS;

Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body.

Julian Rieck, Serguei N Skatchkov, Christian Derst, Misty J Eaton, Rüdiger W Veh , CEREBRAL-ISCHEMIA; RAT-BRAIN; SPERMIDINE/SPERMINE-LIKE IMMUNOREACTIVITY; ORGANIC CATION TRANSPORTERS; ORNITHINE-DECARBOXYLASE; ARGININE DECARBOXYLASE; ALPHA-DIFLUOROMETHYLORNITHINE; INTRACELLULAR SPERMINE; IRREVERSIBLE INHIBITOR; FUNCTIONAL EXPRESSION;

Zinc accelerates respiratory burst termination in human PMN

Annika Droste, Gustavo Chaves, Stefan Stein, Annette Trzmiel, Matthias Schweizer, Hubert Karl, Boris Musset , HUMAN-NEUTROPHILS; SUPEROXIDE-PRODUCTION; NADPH OXIDASE; PROTEIN-KINASE; ALVEOLAR EPITHELIAL-CELLS; GATED PROTON CHANNELS; PLASMA-MEMBRANE DEPOLARIZATION; STIMULATED NEUTROPHILS; VOLTAGE-DEPENDENCE; ELECTRON CURRENTS;

From Pinocytosis to Methuosis-Fluid Consumption as a Risk Factor for Cell Death.

Markus Ritter, Nikolaus Bresgen, Hubert H Kerschbaum , NITRIC-OXIDE SYNTHASE; ION CHANNELS; REGULATORY VOLUME DECREASE; INDOLYL-PYRIDINYL-PROPENONES; CA2+-ACTIVATED K+ CURRENT; HUMAN EPITHELIAL-CELLS; CLC CHLORIDE CHANNELS; NA+/H+ EXCHANGER NHE1; VACUOLAR H+-ATPASE; WATER PERMEABILITY;

Low pH Attenuates Apoptosis by Suppressing the Volume-Sensitive Outwardly Rectifying (VSOR) Chloride Current in Chondrocytes.

Michael Kittl, Martina Winklmayr, Julia Preishuber-Pflügl, Victoria Strobl, Martin Gaisberger, Markus Ritter, Martin Jakab , OSTEOARTHRITIS; ACTIVATION; CARTILAGE; ION CHANNELS; REGULATED ANION CHANNEL; ACIDIFICATION; DECREASE; VOLTAGE-DEPENDENT PROPERTIES; ENDOTHELIAL-CELL APOPTOSIS; STAUROSPORINE;

The proton channel Hv1 is water-impermeable

D. Boytsov, S. Brescia, C. Siligan, Boris Musset, P. Pohl

COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab.

Sanzio Dimai, Lukas Semmler, Ashok Prabhu, Harald Stachelscheid, Judith Huettemeister, Sandra C Klaucke, Philipp Lacour, Florian Blaschke, Jan Kruse, Abdul Parwani, Leif-Hendrik Boldt, Lars Bullinger, Burkert M Pieske, Frank R Heinzel, Felix Hohendanner , NECROSIS-FACTOR-ALPHA; IL-1-BETA; COVID-19; INTERLEUKIN-1; CYTOKINE STORM;

A novel giant non-cholinergic striatal interneuron restricted to the ventrolateral striatum coexpresses Kv3.3 potassium channel, parvalbumin, and the vesicular GABA transporter.

Christian Derst